The search for retroviruses in human cancer cells has advanced with the discoveries of the retroviral reverse transcriptase, DNA hybridization and sequencing techniques, and polymerase chain reaction (PCR) technology. Each technological advancement has led to a better refinement and a better understanding of latent endogenous retroviruses in the human genome. With the recent developments in the Human Genome Project it is to be expected that additional information will be obtained on the role and function of these human retroviruses, their ancestral origin and, if possible, their involvement as a source for emerging new retroviruses.