Nutrients, signal transduction and carcinogenesis

Adv Exp Med Biol. 1995;369:175-83. doi: 10.1007/978-1-4615-1957-7_16.


Choline phospholipids play major roles in cellular regulation in addition to their essential function as structural components of membranes and lipoproteins. The unique functions of choline phospholipids as hormones (platelet activating factor, 1-alkyl, 2-acetylphosphatidylcholine, PAF) and sources (phosphatidylcholine, sphingolipids) of second messengers (sphingosine, diacylglycerol, lysophospholipids, arachidonic acid and its metabolites) may explain how dietary choline influences normal physiological processes as well as a diverse group of pathological processes, including carcinogenesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Choline Deficiency / complications
  • Choline Deficiency / metabolism
  • Humans
  • Liver / metabolism
  • Liver Neoplasms, Experimental / etiology
  • Neoplasms, Experimental / etiology*
  • Nutritional Physiological Phenomena / physiology*
  • Signal Transduction / physiology*