Use of sevoflurane during elective cesarean birth: a comparison with isoflurane and spinal anesthesia

Anesth Analg. 1995 Jul;81(1):90-5. doi: 10.1097/00000539-199507000-00018.


This randomized study compared sevoflurane 1% and isoflurane 0.5% in terms of maternal and neonatal outcomes. In addition, neonatal outcome in both groups was compared with a cohort of patients delivered by cesarean birth using spinal anesthesia. Fifty-five patients presenting for elective cesarean birth under general anesthesia were randomly assigned to receive either sevoflurane 1% or isoflurane 0.5% in a 50% nitrous oxide and oxygen mixture for maintenance. Twenty patients requesting regional anesthesia received a subarachnoid block using 1.5 mL bupivacaine 0.75% in 8.25% dextrose with fentanyl 10 micrograms. Intraoperative hemodynamic variables and perioperative adverse events were recorded. Neonatal data included Apgar scores at 1 and 5 min, umbilical artery gas analysis, neurologic adaptive capacity scores (NACS) at 2 and 24 h, and a modified neonatal behavioral assessment scale (NBAS) at 24 h. Sevoflurane and isoflurane at equianesthetic concentrations (0.46 MAC-h [minimum alveolar anesthetic concentration hours]) were associated with similar blood pressure and heart rate changes during the operation. Blood loss, uterine tone, and perioperative complications were not problematic and were similar with the two drugs. No differences were seen in emergence times or in the time to being judged fit for discharge from the recovery room. Similarly, the level of postoperative comfort was the same in both groups. Comparing the general and the spinal anesthetic groups, no differences could be detected in neonatal outcome. Fluoride concentrations were modestly increased above preoperative levels in maternal and umbilical blood samples after sevoflurane administration.(ABSTRACT TRUNCATED AT 250 WORDS)

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anesthesia, Inhalation*
  • Anesthesia, Obstetrical*
  • Anesthesia, Spinal*
  • Anesthetics, Inhalation / administration & dosage*
  • Apgar Score
  • Blood Pressure / drug effects
  • Bupivacaine / administration & dosage
  • Cesarean Section*
  • Cohort Studies
  • Elective Surgical Procedures
  • Ethers / administration & dosage*
  • Female
  • Fetal Blood / chemistry
  • Heart Rate / drug effects
  • Humans
  • Infant Behavior / drug effects
  • Infant, Newborn
  • Isoflurane / administration & dosage*
  • Methyl Ethers*
  • Nerve Block
  • Neurologic Examination
  • Pregnancy
  • Sevoflurane


  • Anesthetics, Inhalation
  • Ethers
  • Methyl Ethers
  • Sevoflurane
  • Isoflurane
  • Bupivacaine