Class II antigens and disease susceptibility

Annu Rev Med. 1995;46:17-25. doi: 10.1146/annurev.med.46.1.17.

Abstract

The role for HLA typing in autoimmune disease is changing with the recognition that HLA markers can identify patients with poor prognosis in some autoimmune disease. Aggressive therapeutic intervention in patients with such HLA prognostic markers has the potential to improve or prevent progressive disease outcomes in a select group of patients.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / genetics
  • Arthritis, Rheumatoid / therapy
  • Autoimmune Diseases / genetics*
  • Autoimmune Diseases / therapy
  • Diabetes Mellitus, Type 1 / genetics
  • Diabetes Mellitus, Type 1 / therapy
  • Disease Susceptibility / therapy
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease*
  • Histocompatibility Antigens Class II / genetics*
  • Humans
  • Prognosis
  • Risk Factors

Substances

  • Genetic Markers
  • Histocompatibility Antigens Class II