P2-purinergic receptors: subtype-associated signaling responses and structure

Annu Rev Pharmacol Toxicol. 1995;35:541-79. doi: 10.1146/annurev.pa.35.040195.002545.


Extracellular adenine nucleotides interact with P2-purinergic receptors to regulate a broad range of physiological processes. These receptors include the P2Y-, P2U-, P2T-, P2X-, and P2Z-purinergic receptor subtypes. This review focuses on the first three of these receptor subtypes, which couple to G proteins and regulate the inositol lipid, cyclic AMP, and other second-messenger signaling cascades. Both pharmacological data and the occurrence of selectivity of coupling to second-messenger pathways indicate the existence of multiple members in several of the classes of P2-purinergic receptor subtypes. Complementary DNAs cloned for P2Y- and P2U-purinergic receptors predict proteins with seven transmembrane-spanning motifs, typical of that of other G protein-linked receptors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenine Nucleotides / metabolism
  • Amino Acid Sequence
  • Animals
  • Cyclic AMP / metabolism
  • GTP-Binding Proteins / metabolism
  • Humans
  • Inositol / metabolism
  • Molecular Sequence Data
  • Purinergic P2 Receptor Agonists
  • Radioligand Assay
  • Receptors, Purinergic P2 / chemistry
  • Receptors, Purinergic P2 / classification
  • Receptors, Purinergic P2 / metabolism*
  • Second Messenger Systems*
  • Structure-Activity Relationship


  • Adenine Nucleotides
  • Purinergic P2 Receptor Agonists
  • Receptors, Purinergic P2
  • Inositol
  • Cyclic AMP
  • GTP-Binding Proteins