Mitochondrial decay in aging

Biochim Biophys Acta. 1995 May 24;1271(1):165-70. doi: 10.1016/0925-4439(95)00024-x.


Several mitochondrial functions decline with age. The contributing factors include, the intrinsic rate of proton leakage across the inner mitochondrial membrane (a correlate of oxidant formation), decreased membrane fluidity, and decreased levels and function of cardiolipin, which supports the function of many of the proteins of the inner mitochondrial membrane. Oxidants generated by mitochondria appear to be the major source of the oxidative lesions that accumulate with age. Evidence supports the suggestion that age-associated accumulation of mitochondrial deficits due to oxidative damage is likely to be a major contributor to cellular, tissue, and organismal aging.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aging / metabolism*
  • Animals
  • Brain / growth & development
  • Brain / metabolism
  • DNA Damage*
  • DNA, Mitochondrial / genetics*
  • DNA, Mitochondrial / metabolism
  • Humans
  • Lipid Metabolism
  • Liver / growth & development
  • Male
  • Mitochondria / metabolism*
  • Mitochondria / physiology
  • Mitochondria, Liver / metabolism
  • Mutation
  • Proteins / metabolism
  • Rats
  • Rats, Inbred F344


  • DNA, Mitochondrial
  • Proteins