Cap binding complexes and cellular growth control

S Mader; N Sonenberg

doi:10.1016/0300-9084(96)88102-8

Cap binding complexes and cellular growth control

Biochimie. 1995;77(1-2):40-4. doi: 10.1016/0300-9084(96)88102-8.

Authors

S Mader¹, N Sonenberg

Affiliation

¹ Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

PMID: 7599274
DOI: 10.1016/0300-9084(96)88102-8

Abstract

The cap-binding complex eIF-4F plays a major role in the control of translation initiation, and overexpression of its limiting subunit, eIF-4E, leads to the deregulation of cellular growth. The recent cloning of eIF-4E binding proteins (4E-BPs) has uncovered a previously unsuspected pathway for the regulation of eIF-4E activity, through sequestration of eIF-4E as a complex with 4E-BPs.

Publication types

Review

MeSH terms

Cell Division*
Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factor-4F
Gene Expression Regulation / genetics
Peptide Initiation Factors / biosynthesis
Peptide Initiation Factors / metabolism*
Phosphorylation
Protein Biosynthesis / genetics
RNA Cap-Binding Proteins
RNA Caps / metabolism*
RNA-Binding Proteins / genetics
RNA-Binding Proteins / metabolism*

Substances

Eukaryotic Initiation Factor-4E
Eukaryotic Initiation Factor-4F
Peptide Initiation Factors
RNA Cap-Binding Proteins
RNA Caps
RNA-Binding Proteins