Treatment of vitiligo with a topical application of pseudocatalase and calcium in combination with short-term UVB exposure: a case study on 33 patients

Dermatology. 1995;190(3):223-9. doi: 10.1159/000246690.

Abstract

Thirty-three patients with the depigmentation disorder vitiligo were successfully treated with a new topical application of pseudocatalase, calcium and short-term UVB light exposure. First repigmentation occurred in the majority of cases after 2-4 months. Complete repigmentation on the face and dorsum of the hands appeared in 90% of the group. In all patients, active depigmentation was arrested. None of them developed new lesions during treatment. No recurrence of the disease was observed during a 2-year follow-up. The rationale for this pilot study originated from a recent understanding of vitiligo at the molecular level. The involved epidermis produces hydrogen peroxide due to defective tetrahydrobiopterin recycling and increased monoamine oxidase A activity, whereupon catalase is inactivated. In addition, calcium homeostasis is perturbed in the affected skin. The substitution for insufficient catalase by a pseudocatalase together with calcium and UVB exposure lead to effective repigmentation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Aged
  • Calcium / administration & dosage
  • Calcium / therapeutic use*
  • Catalase / administration & dosage
  • Catalase / therapeutic use*
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Humans
  • Hydrogen Peroxide / antagonists & inhibitors
  • Hydrogen Peroxide / metabolism
  • Male
  • Middle Aged
  • Monoamine Oxidase Inhibitors / therapeutic use
  • Photochemotherapy / methods*
  • Pilot Projects
  • Remission Induction
  • Skin Pigmentation / drug effects
  • Skin Pigmentation / radiation effects
  • Ultraviolet Therapy*
  • Vitiligo / drug therapy*
  • Vitiligo / metabolism

Substances

  • Monoamine Oxidase Inhibitors
  • Hydrogen Peroxide
  • pseudocatalase
  • Catalase
  • Calcium