Matching for MHC haplotypes results in improved survival following unrelated bone marrow transplantation

Bone Marrow Transplant. 1995 Mar;15(3):381-5.


Unrelated bone marrow donor-recipient pairs were assessed retrospectively for matching of the HLA-B, -C region (beta-block) and HLA-DR, DQ region (delta block) of the major histocompatibility complex (MHC) using a new DNA-based method referred to as MHC-block typing. The method utilises non-HLA DNA polymorphisms in the MHC as markers of blocks of ancestral haplotypes. Kaplan-Meier analysis of recipients who were matched at both the beta- and delta-blocks revealed a 6 months survival of 54%. Survival was better than for patients who were matched only by conventional criteria, including SSO-typing for class II.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Bone Marrow Transplantation / immunology*
  • Cell Line, Transformed
  • HLA-DQ Antigens / immunology
  • HLA-DR Antigens / immunology
  • Hematologic Diseases / mortality*
  • Hematologic Diseases / therapy
  • Histocompatibility Antigens Class I / immunology*
  • Histocompatibility Antigens Class II / immunology*
  • Histocompatibility Testing / methods*
  • Humans
  • Matched-Pair Analysis
  • Polymerase Chain Reaction
  • Retrospective Studies


  • HLA-DQ Antigens
  • HLA-DR Antigens
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II