Association of Helicobacter pylori and gastric autoimmunity: a population-based study

FEMS Immunol Med Microbiol. 1995 Mar;11(1):65-8. doi: 10.1111/j.1574-695X.1995.tb00079.x.

Abstract

Based on clinical studies, a negative association between Helicobacter pylori and autoimmune corpus gastritis is described. In the present investigation of an unselected population of 1461 adults we can state, however, that there exists a relationship between H. pylori infection and the development of gastric corpus autoimmunity. As confirmation for the gastric autoantibody development through molecular mimicry, a high homology (72% in 25 amino acid overlap) between the beta subunit of H. pylori urease and that of H + K + ATPase, the gastric parietal cell autoantigen, was revealed.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Amino Acid Sequence
  • Animals
  • Antigens, Bacterial / genetics
  • Autoantibodies / blood
  • Autoantigens / genetics
  • Autoimmune Diseases / microbiology*
  • Cohort Studies
  • Estonia
  • Female
  • Gastritis / immunology
  • Gastritis / microbiology*
  • H(+)-K(+)-Exchanging ATPase / genetics
  • Helicobacter Infections / immunology*
  • Humans
  • Immunoglobulin G / blood
  • Male
  • Mice
  • Middle Aged
  • Molecular Sequence Data
  • Parietal Cells, Gastric / enzymology
  • Parietal Cells, Gastric / immunology
  • Rats
  • Sequence Homology, Amino Acid
  • Urease / genetics

Substances

  • Antigens, Bacterial
  • Autoantibodies
  • Autoantigens
  • Immunoglobulin G
  • Urease
  • H(+)-K(+)-Exchanging ATPase