Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation

Immunity. 1994 Nov;1(8):635-45. doi: 10.1016/1074-7613(94)90035-3.


Oct-2, a POU homeodomain protein expressed primarily in B cells, is a powerful transcriptional activator that binds to DNA at sites appropriately placed for major effects on immunoglobulin gene expression. Our examination of B cell development and function in Oct-2 null mice did not support an essential role for Oct-2 early in B cell development. Rather, Oct-2 was required later, when B cells were induced to differentiate to antibody-secreting cells. We show here that Oct-2 is not required for normal immunoglobulin production by mature B lymphocytes. Instead, it is essential for a normal proliferative response to polyclonal mitogens. Responses to signals from activated T cells are unaffected. The requirement for Oct-2 maps to an early activation step in G1, during which B cells make the commitment to progress through the cell cycle and to divide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibody-Producing Cells / metabolism
  • Antigens, Differentiation, B-Lymphocyte / biosynthesis
  • Antigens, Differentiation, B-Lymphocyte / genetics
  • B-Lymphocytes / immunology*
  • Bone Marrow
  • Cell Differentiation
  • DNA-Binding Proteins / physiology
  • G1 Phase*
  • Immunoglobulin Isotypes / biosynthesis
  • Immunotherapy, Adoptive
  • Lymphocyte Activation*
  • Lymphocyte Cooperation
  • Mice
  • Mice, SCID
  • Mutagenesis, Insertional
  • Octamer Transcription Factor-2
  • Transcription Factors / genetics
  • Transcription Factors / physiology*


  • Antigens, Differentiation, B-Lymphocyte
  • DNA-Binding Proteins
  • Immunoglobulin Isotypes
  • Octamer Transcription Factor-2
  • Pou2f2 protein, mouse
  • Transcription Factors