Non-synergistic relaxant effects of vasoactive intestinal polypeptide and SIN-1 in human isolated cavernous artery and corpus cavernosum

Eur J Pharmacol. 1995 Apr 4;276(3):277-80. doi: 10.1016/0014-2999(95)00081-u.

Abstract

Since vasoactive intestinal peptide (VIP) and nitric oxide (NO) are considered to be non-adrenergic, non-cholinergic (NANC) inhibitory mediators in human penile erectile tissue, the goal of this study was to discover possible synergistic effects of exogeneous VIP and the NO donor 3-morpholino-sydnonimine (SIN-1) in human isolated cavernous arteries and cavernosal smooth muscle. In contrast to VIP, SIN-1 elicited complete and reproducible relaxant actions. Combined administration of VIP and SIN-1 revealed non-synergistic, independent relaxant effects in both investigated tissues. The results do not favour a combined administration of VIP and SIN-1 as a new therapeutic approach in the treatment of erectile dysfunction.

MeSH terms

  • Arteries / drug effects
  • Drug Interactions
  • Humans
  • In Vitro Techniques
  • Isometric Contraction / drug effects
  • Male
  • Molsidomine / analogs & derivatives*
  • Molsidomine / pharmacology
  • Muscle Relaxation / drug effects
  • Muscle, Smooth / drug effects*
  • Muscle, Smooth, Vascular / drug effects*
  • Penis / blood supply
  • Penis / drug effects*
  • Phenylephrine / pharmacology
  • Regional Blood Flow / drug effects
  • Vasoactive Intestinal Peptide / pharmacology*
  • Vasodilator Agents / pharmacology*

Substances

  • Vasodilator Agents
  • Phenylephrine
  • Vasoactive Intestinal Peptide
  • linsidomine
  • Molsidomine