Twelve patients with sickle cell disease (SCD), eleven males within the age range 21 to 24 years and one female, fourteen years old presenting with cephalhaematoma at the Haematology Day Care Unit (H.D.C.U.) of the University College Hospital, Ibadan during a three year period were reviewed. Only one patient was sickle cell haemoglobin SC (HbSC) while others were homozygous (HbSS). They all presented with a triad of symptoms consisting of fever, headaches and scalp swelling. Significant findings include the exclusive male preponderance and the almost exclusive presentation in HbSS patients. Treatment include analgesic and intravenous fluids.