T-cell large granular lymphocytic leukemia following orthotopic liver transplantation

Am J Hematol. 1995 Jul;49(3):216-20. doi: 10.1002/ajh.2830490307.


Aggressive T-cell neoplasms are an infrequent complication of allogeneic organ and bone marrow transplantation. To date, chronic T-cell lymphoproliferative malignancies have not been described. The present case documents the occurrence of a T-cell large granular lymphocytic leukemia (T-LGL) in a patient following orthotopic liver transplantation. Genotype studies showed a clonal T-cell receptor beta-chain gene rearrangement. A unique feature was the detection of a specific chromosomal deletion at 1p32 involving the tal-1 gene, an abnormality previously described only in aggressive T-cell neoplasms.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Base Sequence
  • Chromosome Deletion
  • Chromosomes, Human, Pair 1
  • Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
  • Genotype
  • Hepatitis B / complications
  • Humans
  • Indians, North American
  • Leukemia, T-Cell / etiology*
  • Leukemia, T-Cell / genetics
  • Liver Cirrhosis / surgery
  • Liver Cirrhosis / virology
  • Liver Transplantation / adverse effects*
  • Male
  • Molecular Sequence Data