Elevated concentration of plasma homocyst(e)ine is an independent risk factor for clinical atherosclerosis. In this study, the concentration of plasma homocyst(e)ine in men who lacked a history of atherosclerotic disease was correlated with hemodynamic, rheological and biochemical parameters. Hypertensive subjects had higher concentrations of plasma homocyst(e)ine than normotensive subjects. Positive correlations were found between concentrations of plasma homocyst(e)ine and several risk factors, but some of these correlations disappeared when they were adjusted for other variables. However, multivariate analyses demonstrated that systolic blood pressure, plasma uric acid, and hematocrit were predictors of concentrations of plasma homocyst(e)ine, after adjusting for certain risk factors. The possible significance of these interrelationships in atherogenesis require further study.