A Family of Molecules Related to Collapsin in the Embryonic Chick Nervous System

Neuron. 1995 Jun;14(6):1131-40. doi: 10.1016/0896-6273(95)90261-9.

Abstract

Signaling molecules with either attractive or repulsive effects on specific growth cones are likely to play a role in guiding axons to their appropriate targets. A chick brain glycoprotein, collapsin, has been shown to be a good candidate for a repulsive guidance cue. We report here the discovery of four new molecules related to collapsin in chick brains. All contain a semaphorin domain. One is structurally very similar to collapsin but is only 50% identical in its amino acid sequence. We have named it collapsin-2. The collapsin-related genes exhibit distinct but overlapping patterns of mRNA expression in the developing spinal cord and the developing visual system. This family of collapsin-related molecules could potentially act as repulsive cues toward specific neuronal populations.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Avian Proteins
  • Base Sequence
  • Brain / embryology*
  • Brain / metabolism
  • Brain Chemistry*
  • Chick Embryo
  • DNA, Complementary / chemistry
  • DNA, Complementary / isolation & purification
  • Extremities / embryology
  • Gene Expression
  • Glycoproteins / analysis*
  • Glycoproteins / chemistry
  • Glycoproteins / genetics
  • Intercellular Signaling Peptides and Proteins
  • Molecular Sequence Data
  • Nerve Growth Factors / analysis*
  • Optic Nerve / chemistry
  • Optic Nerve / embryology
  • RNA, Messenger / analysis
  • Retina / chemistry
  • Retina / embryology
  • Semaphorin-3A
  • Spinal Cord / chemistry
  • Spinal Cord / embryology*
  • Superior Colliculi / chemistry
  • Superior Colliculi / embryology

Substances

  • Avian Proteins
  • DNA, Complementary
  • Glycoproteins
  • Intercellular Signaling Peptides and Proteins
  • Nerve Growth Factors
  • RNA, Messenger
  • SEMA3D protein, Gallus gallus
  • Semaphorin-3A

Associated data

  • GENBANK/U28240
  • GENBANK/U28241
  • GENBANK/U28242
  • GENBANK/U28243