Expression of Xkl-1, a Xenopus gene related to mammalian c-kit, in dorsal embryonic tissue

Mech Dev. 1995 Mar;50(1):57-69. doi: 10.1016/0925-4773(94)00325-h.


In mice, the Kit receptor tyrosine kinase and its ligand, Steel factor, are required for melanogenesis, hematopoesis and gametogenesis We have identified a Xenopus gene, Xkl-1 (Xenopus Kit-like-1) whose predicted protein has striking sequence identity in the catalytic domain and kinase insert to that of c-kit. Xkl-1 is expressed only in dorsal tissues such as the nervous system, notochord and somites of neurulae. Ultraviolet irradiated embryos and animal caps treated with basic FGF unexpectedly express Xkl-1, since they are considered to develop only ventral type tissues. These observations raise the hypothesis that Xkl-1 is involved in Xenopus dorsal development and that dorsal tissues inhibit the expression of Xkl-1 in ventral structures.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Catalysis
  • Cloning, Molecular
  • Gene Expression Regulation, Developmental / physiology*
  • Gestational Age
  • Molecular Sequence Data
  • Muridae / genetics*
  • Protein Structure, Tertiary
  • Receptor Protein-Tyrosine Kinases / genetics*
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Xenopus laevis / genetics*


  • Receptor Protein-Tyrosine Kinases