Mapping of gene loci in the Q13-Q15 region of chromosome 12

Chromosome Res. 1995 Jun;3(4):261-2. doi: 10.1007/BF00713052.

Abstract

The gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13-q15 region of chromosome 12. Using fluorescence in situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and ordered these loci, together with a number of Genethon microsatellite markers. GLI and CHOP localize to 12q13.3-14.1, CDK4 to 12q14 and MDM2 to 12q14.3-q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CCAAT-Enhancer-Binding Proteins*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 12*
  • Cyclin-Dependent Kinase 4
  • Cyclin-Dependent Kinases*
  • DNA-Binding Proteins / genetics*
  • Genetic Markers / genetics
  • Humans
  • In Situ Hybridization, Fluorescence
  • Nuclear Proteins*
  • Oncogene Proteins / genetics*
  • Protein Serine-Threonine Kinases / genetics*
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-mdm2
  • Trans-Activators
  • Transcription Factor CHOP
  • Transcription Factors / genetics*
  • Zinc Finger Protein GLI1

Substances

  • CCAAT-Enhancer-Binding Proteins
  • DDIT3 protein, human
  • DNA-Binding Proteins
  • Genetic Markers
  • Nuclear Proteins
  • Oncogene Proteins
  • Proto-Oncogene Proteins
  • Trans-Activators
  • Transcription Factors
  • Zinc Finger Protein GLI1
  • Transcription Factor CHOP
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2
  • Protein Serine-Threonine Kinases
  • CDK4 protein, human
  • Cyclin-Dependent Kinase 4
  • Cyclin-Dependent Kinases