Unawareness of smell loss in normal aging and Alzheimer's disease: discrepancy between self-reported and diagnosed smell sensitivity

J Gerontol B Psychol Sci Soc Sci. 1995 Jul;50(4):P187-92. doi: 10.1093/geronb/50b.4.p187.

Abstract

Awareness of loss in smell sensitivity was assessed in 80 normal elderly subjects, 80 patients with probable Alzheimer's disease (AD), and 80 patients with sinusitis by comparing measured smell sensitivity to questionnaire-based, self-reported sensitivity. Both AD patients and sinusitis patients had significantly poorer diagnosed smell sensitivity than the normal elderly. Both patient groups had thresholds which on average were about nine times more concentrated than those of the normal elderly. However, 74% of the AD patients and 77% of the normal elderly with smell loss reported normal smell sensitivity. In contrast, only 8% of the sinusitis patients with loss reported normal smell sensitivity.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Alzheimer Disease / complications*
  • Awareness*
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Olfaction Disorders / diagnosis*
  • Olfaction Disorders / etiology
  • Olfaction Disorders / physiopathology
  • Olfaction Disorders / psychology
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Sensory Thresholds
  • Sinusitis / complications
  • Smell*
  • Surveys and Questionnaires
  • Taste