Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains

Cell. 1995 Jul 14;82(1):57-65. doi: 10.1016/0092-8674(95)90052-7.


Lipomas are one of the most common mesenchymal neoplasms in humans. They are characterized by consistent cytogenetic aberrations involving chromosome 12 in bands q14-15. Interestingly, this region is also the site of rearrangement for other mesenchymally derived tumors. This study demonstrates that HMGI-C, an architectural factor that functions in transcriptional regulation, has been disrupted by rearrangement at the 12q14-15 chromosomal breakpoint in lipomas. Chimeric transcripts were isolated from two lipomas in which HMGI-C DNA-binding domains (AT hook motifs) are fused to either a LIM or an acidic transactivation domain. These results, identifying a gene rearranged in a benign neoplastic process that does not proceed to a malignancy, suggest a role for HMGI-C in adipogenesis and mesenchyme differentiation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 12
  • Cloning, Molecular
  • DNA, Neoplasm / genetics*
  • DNA, Neoplasm / metabolism
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / physiology
  • Gene Expression Regulation, Neoplastic / genetics*
  • Gene Rearrangement / genetics*
  • HMGA2 Protein
  • High Mobility Group Proteins / genetics*
  • High Mobility Group Proteins / physiology
  • Humans
  • Lipoma / chemistry
  • Lipoma / genetics*
  • Mesoderm
  • Molecular Sequence Data
  • RNA, Messenger / analysis
  • RNA, Neoplasm / analysis
  • Transcription, Genetic / genetics
  • Transcriptional Activation


  • DNA, Neoplasm
  • DNA-Binding Proteins
  • HMGA2 Protein
  • High Mobility Group Proteins
  • RNA, Messenger
  • RNA, Neoplasm

Associated data

  • GENBANK/U28131
  • GENBANK/U28132