Mitochondrial DNA mutations in normal and tumor tissues from breast cancer patients

M S Bianchi; N O Bianchi; G Bailliet

doi:10.1159/000134072

Mitochondrial DNA mutations in normal and tumor tissues from breast cancer patients

Cytogenet Cell Genet. 1995;71(1):99-103. doi: 10.1159/000134072.

Authors

M S Bianchi¹, N O Bianchi, G Bailliet

Affiliation

¹ Instituto Multidisciplinario de Biologia Celular, La Plata, Argentina.

PMID: 7606938
DOI: 10.1159/000134072

Abstract

We have characterized the mtDNA in normal and breast cancer tissues from seven patients. Both types of tissue showed point mutation heteroplasmies and extensive deletions of the mtDNA. The analysis of these polymorphisms allowed us to infer the mtDNA composition of the breast cell that underwent malignant transformation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Base Sequence
Breast Neoplasms / genetics*
DNA Primers
DNA, Mitochondrial*
Female
Gene Deletion
Humans
Middle Aged
Molecular Sequence Data
Mutation*
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length

Substances

DNA Primers
DNA, Mitochondrial