Outer membrane permeability of beta-lactamase inhibitors in Pseudomonas aeruginosa

FEMS Microbiol Lett. 1995 Jun 15;129(2-3):251-4. doi: 10.1111/j.1574-6968.1995.tb07588.x.

Abstract

Evaluation of four beta-lactamase inhibitors in terms of their outer membrane permeability in Pseudomonas aeruginosa revealed that sulbactam and tazobactam diffused most efficiently and equally well. That of BRL42715 appeared to be a factor of ten lower than that of the above two, but it showed the strongest beta-lactamase inhibitory activity. This is most likely due to its better beta-lactamase inactivating activity. BRL42715 at 1.56 micrograms ml-1 lowered the minimum inhibitory concentrations of ceftazidime and imipenem in a strain producing fully derepressed beta-lactamase and an undetectable level of the outer membrane protein OprD2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Membrane / physiology
  • Cell Membrane Permeability
  • Mutation
  • Pseudomonas aeruginosa / physiology*
  • beta-Lactamase Inhibitors*
  • beta-Lactamases / genetics

Substances

  • beta-Lactamase Inhibitors
  • beta-Lactamases