The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors

Gene. 1995 Jun 14;159(1):131-5. doi: 10.1016/0378-1119(95)00061-a.


We report the cloning of a cDNA encoding GliPR (glioma pathogenesis-related protein), a protein that is structurally similar to plant pathogenesis-related proteins. The GLIPR gene is highly expressed in the human brain tumor, glioblastoma multiforme/astrocytoma, but neither in normal fetal or adult brain tissue, nor in other nervous system tumors. GliPR shares up to 50% amino acid (aa) homology with plant pathogenesis-related proteins, group 1, over a region that comprises almost two thirds of the protein. We speculate that there may be functional similarities between the human and plant proteins as well.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Astrocytoma
  • Base Sequence
  • Brain Neoplasms / chemistry
  • Brain Neoplasms / genetics*
  • Cloning, Molecular
  • DNA, Complementary / analysis
  • Gene Expression Regulation, Neoplastic*
  • Glioblastoma / chemistry
  • Glioblastoma / genetics*
  • Humans
  • Membrane Proteins
  • Molecular Sequence Data
  • Neoplasm Proteins / chemistry
  • Neoplasm Proteins / genetics*
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / genetics*
  • Plant Proteins / genetics*
  • RNA, Messenger / analysis
  • RNA, Neoplasm / analysis
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Tumor Cells, Cultured


  • DNA, Complementary
  • GLIPR1 protein, human
  • Membrane Proteins
  • Neoplasm Proteins
  • Nerve Tissue Proteins
  • Plant Proteins
  • RNA, Messenger
  • RNA, Neoplasm
  • pathogenesis-related proteins, plant

Associated data

  • GENBANK/U16307