Human herpesvirus-6 infection in children with first febrile seizures

J Pediatr. 1995 Jul;127(1):95-7. doi: 10.1016/s0022-3476(95)70263-6.


We evaluated febrile convulsions prospectively in 42 children to investigate the association between acute human herpesvirus-6 (HHV-6) infection and first-time febrile convulsions, using both virologic and serologic methods. Eight children had primary HHV-6 infection documented by viral culture and an additional three by acute- and convalescent-phase serologic studies. These findings indicate that acute HHV-6 infection is a frequent cause of febrile convulsions in young children.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Cerebrospinal Fluid / virology
  • Child
  • Exanthema Subitum / complications*
  • Exanthema Subitum / virology
  • Herpesvirus 6, Human / isolation & purification*
  • Humans
  • Otitis Media / complications
  • Prospective Studies
  • Seizures, Febrile / complications
  • Seizures, Febrile / etiology*
  • Seizures, Febrile / virology