Intravenous injections of donor sperm may possibly be of value to AIDS patients. The immunological basis for this proposal is reviewed in detail. Donor sperm introduced into the blood of a healthy patient produces anti-sperm antibodies which may become attached to the T-cells and cause their depletion. Reintroduction of donor sperm into the blood of an AIDS patient may reverse the pathogenesis by the donor sperm combining with anti-sperm antibodies so allowing the T-cells to recover. HIV is just the most common among the occupational viral infections of AIDS patients. A clinical trial is proposed.