The possible roles of sperm and sperm antibodies in the pathogenesis and treatment of AIDS

Med Hypotheses. 1995 Mar;44(3):155-8. doi: 10.1016/0306-9877(95)90127-2.


Intravenous injections of donor sperm may possibly be of value to AIDS patients. The immunological basis for this proposal is reviewed in detail. Donor sperm introduced into the blood of a healthy patient produces anti-sperm antibodies which may become attached to the T-cells and cause their depletion. Reintroduction of donor sperm into the blood of an AIDS patient may reverse the pathogenesis by the donor sperm combining with anti-sperm antibodies so allowing the T-cells to recover. HIV is just the most common among the occupational viral infections of AIDS patients. A clinical trial is proposed.

MeSH terms

  • Acquired Immunodeficiency Syndrome / physiopathology*
  • Acquired Immunodeficiency Syndrome / therapy*
  • Antibody Formation*
  • CD4-Positive T-Lymphocytes / immunology
  • HIV / immunology
  • HIV / pathogenicity*
  • HIV Infections / physiopathology
  • HIV Infections / therapy
  • Humans
  • Male
  • Models, Biological
  • Spermatozoa / immunology
  • Spermatozoa / physiology*
  • Spermatozoa / transplantation*