Laboratory markers of colonoscopic activity in ulcerative colitis and Crohn's colitis

Scand J Gastroenterol. 1995 Apr;30(4):356-60. doi: 10.3109/00365529509093290.


Background: Previous studies have not identified a convenient laboratory marker of colonoscopic activity in Crohn's colitis or ulcerative colitis.

Methods: Twenty-eight patients with either ulcerative colitis or Crohn's colitis undergoing colonoscopy by the same observed had laboratory measurements of serum albumin, orosomucoid, C-reactive protein, plasma viscosity, haemoglobin, leucocyte and platelet counts, and faecal alpha-1-antitrypsin from single non-lyophilized samples. Multiple linear regression was performed using each laboratory variable as the dependent variable and the lengths of each grade of endoscopic activity as the explanatory variables.

Results: Multiple regression analysis using all the endoscopic grades of acute activity showed significant correlations with faecal alpha-1-antitrypsin (p < 0.001), serum albumin (p < 0.001), C-reactive protein (p = 0.02), and plasma viscosity (p = 0.03).

Conclusions: The highest multiple correlation coefficients were obtained with faecal alpha-1-antitrypsin (r = 0.82) and serum albumin (r = 0.80), and these measurements can be recommended as convenient markers of endoscopic activity in these diseases.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Biomarkers / analysis
  • Biomarkers / blood
  • Blood Viscosity
  • C-Reactive Protein / analysis
  • Colitis, Ulcerative / blood
  • Colitis, Ulcerative / diagnosis*
  • Colitis, Ulcerative / metabolism
  • Colonoscopy*
  • Crohn Disease / blood
  • Crohn Disease / diagnosis*
  • Crohn Disease / metabolism
  • Feces / chemistry
  • Humans
  • Middle Aged
  • Predictive Value of Tests
  • Prospective Studies
  • Regression Analysis
  • Serum Albumin / analysis
  • alpha 1-Antitrypsin / analysis


  • Biomarkers
  • Serum Albumin
  • alpha 1-Antitrypsin
  • C-Reactive Protein