ICE-like proteases in apoptosis

Trends Biochem Sci. 1995 May;20(5):198-202. doi: 10.1016/s0968-0004(00)89007-6.


The discovery of structural and functional similarities between the product of the nematode cell-death gene ced-3 and mammalian interleukin-1 beta-converting enzyme (ICE) is providing important insights into the molecular mechanism of apoptosis. This article summarizes the current knowledge of ICE and its homologues, and how these may be involved in regulating apoptosis.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Apoptosis / genetics*
  • Caenorhabditis elegans / genetics*
  • Caspase 1
  • Cysteine Endopeptidases / physiology*
  • Humans
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Structure-Activity Relationship


  • Cysteine Endopeptidases
  • Caspase 1