Significance of inflammatory cervical smears

APMIS. 1995 Apr;103(4):273-8. doi: 10.1111/j.1699-0463.1995.tb01106.x.

Abstract

Two hundred and fifty-seven women attending a Maternal and Child Health Centre (MCH) were examined for different colposcopic and histological patterns associated with cervical inflammation as detected by cytology and for their association with different gynaecological infections. The cytodiagnosis revealed inflammation in 207 women (80.5%) and non-inflammation in 49 (19.5%); one smear was inadequate for evaluation. Fifty-six per cent of the women with inflammation and 20% with non-inflammation had an atypical transformation zone (ATZ), the risk of ATZ being 4.9-fold higher in those with inflammation. Biopsies from 128 women with abnormal colposcopy revealed morphological changes suggestive of human papillomavirus (HPV) in 89 (69.5%) and dysplasia of varying grades in 8 (6.3%). Seventy per cent of histologically diagnosed HPV lesions stained immunohistochemically, whereas 84% reacted with a biotinylated Pan-HPV probe by DNA in situ hybridization (DISH). In addition to HPV, chlamydia (OR 15.6, 95% CI 2.2, 311.6), T. vaginalis (OR 18.4), bacterial vaginosis (OR 24.7, 95% CI 3.5, 492) and herpes simplex virus (OR 4.9, 95% CI 1.4, 20.9) were significantly associated with inflammatory smears. Of 11 dysplasias detected by colposcopy and confirmed by biopsy, 8 (72.7%) had inflammatory cytology in the initial Pap smears. Thus a large proportion of women with inflammatory smears had multiple gynaecological infections and may be at increased risk of developing preneoplastic or neoplastic changes. Furthermore, they risk transmitting the infections to their partners.

MeSH terms

  • Adolescent
  • Adult
  • Cervix Uteri / microbiology
  • Cervix Uteri / pathology*
  • Cervix Uteri / virology
  • Colposcopy
  • Female
  • Humans
  • Infections / pathology*
  • Middle Aged
  • Papillomaviridae*
  • Papillomavirus Infections / pathology*
  • Papillomavirus Infections / virology
  • Tumor Virus Infections / pathology*
  • Tumor Virus Infections / virology
  • Uterine Cervical Dysplasia / pathology
  • Uterine Cervicitis / microbiology
  • Uterine Cervicitis / pathology*
  • Uterine Cervicitis / virology