Vegetable and animal products as determinants of colon cancer risk in Dutch men and women

Cancer Causes Control. 1995 May;6(3):225-34. doi: 10.1007/BF00051794.


To examine the relationship between colon cancer and food groups from vegetable or animal sources and their possible interactions with gender, we analyzed data from a Dutch case-control study. Dietary patterns were assessed for 232 colon cancer cases and 259 population controls. In multivariate analyses, the consumption of vegetables was associated significantly with reduced colon-cancer risk (odds ratio [OR] for highest cf lowest quartile of consumption = 0.4, 95 percent confidence interval [CI] = 0.2-0.7, P-trend = 0.0004). Consumption of fresh red meat was associated positively with risk in women (OR = 2.4, 95% CI = 1.0-5.7, P-trend = 0.04), especially for those with a high consumption of red meat relative to the consumption of vegetables and fruits (OR = 3.1). For men, no association with consumption of fresh red meat was found (OR = 0.9). No clear associations were found for other products of vegetable or animal origin. The results of this Dutch case-control study support the preventive potential of a high-vegetable diet in colon cancer risk. This study suggest this may be important for women consuming a diet high in red meat.

MeSH terms

  • Aged
  • Animals
  • Case-Control Studies
  • Colonic Neoplasms / epidemiology*
  • Energy Intake
  • Feeding Behavior*
  • Female
  • Food*
  • Fruit
  • Humans
  • Life Style
  • Male
  • Meat*
  • Middle Aged
  • Multivariate Analysis
  • Netherlands / epidemiology
  • Risk Factors
  • Sex Factors
  • Vegetables*
  • Vitamins / administration & dosage


  • Vitamins