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. 1995 Apr;5(2):180-9.
doi: 10.1016/0959-437x(95)80006-9.

Structure and Function of DNA-binding Proteins


Structure and Function of DNA-binding Proteins

H C Nelson. Curr Opin Genet Dev. .


The past year has seen the determination of over three dozen new structures of DNA-binding proteins. Highlights of new structural motifs include the DNA-binding domain of p53 tumor suppressor and the amino-terminal fragment of Escherichia coli DNA topoisomerase I. Other structures illustrate variations of known structural motifs, including co-crystals of helix-turn-helix, basic helix-loop-helix, and zinc finger proteins.

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