Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine

Int Arch Allergy Immunol. May-Jun 1995;107(1-3):420. doi: 10.1159/000237063.
No abstract available

MeSH terms

  • Cytochrome P-450 CYP2D6
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme Inhibitors
  • Cytochrome P-450 Enzyme System / metabolism*
  • Humans
  • Inactivation, Metabolic
  • Loratadine / pharmacokinetics*
  • Microsomes, Liver / enzymology*
  • Mixed Function Oxygenases / antagonists & inhibitors
  • Mixed Function Oxygenases / metabolism*
  • Piperidines / metabolism
  • Pyridines / metabolism

Substances

  • Cytochrome P-450 Enzyme Inhibitors
  • Piperidines
  • Pyridines
  • Loratadine
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • CYP3A protein, human
  • Cytochrome P-450 CYP2D6
  • Cytochrome P-450 CYP3A
  • desloratadine