Bacterial translocation from the gastrointestinal tract

Trends Microbiol. 1995 Apr;3(4):149-54. doi: 10.1016/s0966-842x(00)88906-4.


Bacterial translocation is defined as the passage of viable indigenous bacteria from the gastrointestinal tract to extraintestinal sites, such as the mesenteric-lymph-node complex, liver, spleen and bloodstream. Three major mechanisms promote bacterial translocation: intestinal bacterial overgrowth, deficiencies in host immune defenses and increased permeability or damage to the intestinal mucosal barrier.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacterial Infections / immunology
  • Bacterial Infections / microbiology*
  • Bacterial Physiological Phenomena*
  • Cell Movement
  • Digestive System / microbiology*
  • Intestinal Mucosa / microbiology