Lack of association between an interleukin-1 receptor antagonist gene polymorphism and systemic lupus erythematosus

Dis Markers. 1995 Mar;12(2):135-9. doi: 10.1155/1994/464787.

Abstract

Non-MHC linked genes may contribute to genetic predisposition to the development of systemic lupus erythematosus. The possibility that cytokine genes may be involved was raised by the observation of increased frequency in expression of an uncommon allele of an interleukin-1 receptor antagonist gene polymorphism and SLE in a recent U.K. study. We have not been able to show any significant differences in expression of this allele in SLE patients as a whole or in any patient subgroups. Our results actually show a slight decrease in the expression of this allele in SLE patients compared with healthy controls and in SLE patients with malar rash compared with SLE patients without malar rash.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Humans
  • Interleukin 1 Receptor Antagonist Protein
  • Lupus Erythematosus, Systemic / genetics*
  • Polymorphism, Genetic*
  • Receptors, Interleukin-1 / antagonists & inhibitors*
  • Sialoglycoproteins / genetics*

Substances

  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein
  • Receptors, Interleukin-1
  • Sialoglycoproteins