Serotypes and resistance patterns of Streptococcus pneumoniae causing systemic disease in northern Norway

Eur J Clin Microbiol Infect Dis. 1995 Mar;14(3):229-34. doi: 10.1007/BF02310362.


During the period 1985-1990, Streptococcus pneumoniae was isolated form 97 patients with systemic pneumococcal disease in Northern Norway. Systemic disease occurred most frequently in the age groups 0-4 years and > 60 years. An increasing incidence was observed, especially among children less than five years old. Serotypes covered by the 23-valent pneumococcal polysaccharide vaccine were found in 86 of 97 (88.7%) isolates. The vaccine did not cover 16.7% of the systemic isolates from children less than five years old. Reduced sensitivity to penicillin was found in one isolate (1.0%) which was resistant to ampicillin, doxycycline and chloramphenicol. The E-test and the Rosco agar diffusion test differed in sensitivity to penicillin, chloramphenicol, ciprofloxacin and erythromycin. Three serotype 12F strains showed unusual cross-resistance to chloramphenicol and erythromycin.

MeSH terms

  • Adolescent
  • Adult
  • Age Distribution
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Bacteremia / drug therapy
  • Bacteremia / epidemiology*
  • Bacteriological Techniques
  • Child
  • Child, Preschool
  • Drug Resistance, Microbial
  • Humans
  • Incidence
  • Microbial Sensitivity Tests
  • Middle Aged
  • Norway / epidemiology
  • Pneumococcal Infections / drug therapy
  • Pneumococcal Infections / epidemiology*
  • Serotyping
  • Streptococcus pneumoniae / classification
  • Streptococcus pneumoniae / drug effects*


  • Anti-Bacterial Agents