hCAP-18, a cathelin/pro-bactenecin-like Protein of Human Neutrophil Specific Granules

FEBS Lett. 1995 Jul 10;368(1):173-6. doi: 10.1016/0014-5793(95)00634-l.

Abstract

A 19 kDa protein was identified in specific granules of human neutrophils. A full-length cDNA clone was isolated from a human CML cDNA library, based on amino-acid sequences of isolated tryptic fragments. This clone includes the recently identified cDNA for FALL-39/CAP-18. Aminoacid sequences of proteolytic fragments derived both from the conserved N-terminal cathelin-like region and the highly variable C-terminal region characteristic of this family of bactericidal, LPS binding proteins, were in complete agreement with the sequence deduced from the cDNA. Thus, the 19 kDa protein is hCAP-18, stored as a 'pro-peptide' in specific granules.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antimicrobial Cationic Peptides*
  • Base Sequence
  • Carrier Proteins / analysis*
  • Carrier Proteins / chemistry
  • Cathelicidins
  • Cytoplasmic Granules / chemistry*
  • DNA Primers
  • Humans
  • Molecular Sequence Data
  • Neutrophils / chemistry*
  • Peptides, Cyclic / chemistry
  • Proteins / chemistry

Substances

  • Antimicrobial Cationic Peptides
  • Carrier Proteins
  • Cathelicidins
  • DNA Primers
  • Peptides, Cyclic
  • Proteins
  • cathelin
  • bactenecin
  • CAP18 lipopolysaccharide-binding protein

Associated data

  • GENBANK/X89658