Dietary flour supplementation decreases post-menopausal hot flushes: effect of soy and wheat

Maturitas. 1995 Apr;21(3):189-95. doi: 10.1016/0378-5122(95)00899-v.

Abstract

Plants contain compounds with oestrogen-like action called phytoestrogens. Soy contains daidzin, a potent phytoestrogen, and wheat flour contains less potent enterolactones. We aimed to show in 58 postmenopausal women (age 54, range 30-70 years) with at least 14 hot flushes per week, that their daily diet supplemented with soy flour (n = 28) could reduce flushes compared with wheat flour (n = 30) over 12 weeks when randomised and double blind. Hot flushes significantly decreased in the soy and wheat flour groups (40% and 25% reduction, respectively < 0.001 for both) with a significant rapid response in the soy flour group in 6 weeks (P < 0.001) that continued. Menopausal symptom score decreased significantly in both groups (P < 0.05). Urinary daidzein excretion confirmed compliance. Vaginal cell maturation, plasma lipids and urinary calcium remained unchanged. Serum FSH decreased and urinary hydroxyproline increased in the wheat flour group.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Double-Blind Method
  • Estrogens, Non-Steroidal / administration & dosage*
  • Female
  • Flour*
  • Flushing / prevention & control*
  • Humans
  • Isoflavones*
  • Middle Aged
  • Phytoestrogens
  • Plant Preparations
  • Postmenopause*
  • Soybeans*
  • Triticum*

Substances

  • Estrogens, Non-Steroidal
  • Isoflavones
  • Phytoestrogens
  • Plant Preparations