A novel receptor involved in T-cell activation

Nature. 1995 Jul 20;376(6537):260-3. doi: 10.1038/376260a0.


Optimal T-cell activation and T-cell expansion require triggering by T-cell antigen receptors and co-stimulatory signals provided by accessory cells. A major co-stimulatory pathway involves crosslinking the CD28 molecule on T cells by its ligands CD80 or CD86 expressed on antigen-presenting cells. But recent studies on CD28-deficient mice have indicated that CD28 is not required for all T-cell responses and that additional T-cell co-stimulatory pathways exist. Here we describe a novel glycoprotein, of relative molecular mass 70,000 (M(r) 70K), designated SLAM, that belongs to the immunoglobulin gene superfamily, which is involved in T-cell stimulation. SLAM is constitutively expressed on peripheral-blood CD45ROhigh memory T cells, T-cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Engagement of SLAM enhances antigen-specific proliferation and cytokine production by T cells carrying the CD4 antigen (CD4+). Particularly, the production of interferon-gamma (IFN-gamma) is strongly upregulated, even in T helper type 2 (Th2) CD4+ T-cell clones, whereas no induction of interleukin (IL)-4 or IL-5 production was observed in Th1 clones. In addition, the engagement of SLAM induces directly the proliferation of CD4+ T-cell clones and preactivated T cells, in the absence of any other stimuli, and without CD28 involvement. Thus SLAM is a novel receptor on T cells that, when engaged, potentiates T-cell expansion in a CD28-independent manner and induces a Th0/Th1 cytokine production profile.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal / immunology
  • Antigens, CD
  • Base Sequence
  • Cell Line
  • Cloning, Molecular
  • Cytokines / biosynthesis
  • DNA Primers
  • Escherichia coli
  • Glycoproteins / immunology*
  • Humans
  • Immunoglobulins / immunology*
  • Interferon-gamma / biosynthesis
  • Leukocyte Common Antigens / immunology
  • Lymphocyte Activation*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Receptors, Antigen, T-Cell / immunology*
  • Receptors, Cell Surface
  • Signaling Lymphocytic Activation Molecule Family Member 1
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocytes / immunology*


  • Antibodies, Monoclonal
  • Antigens, CD
  • Cytokines
  • DNA Primers
  • Glycoproteins
  • Immunoglobulins
  • Receptors, Antigen, T-Cell
  • Receptors, Cell Surface
  • Signaling Lymphocytic Activation Molecule Family Member 1
  • Interferon-gamma
  • Leukocyte Common Antigens

Associated data

  • GENBANK/U33017