Effects of selective serotonergic agonists on aggressive behavior in rats

Pharmacol Biochem Behav. 1995 Apr;50(4):671-4. doi: 10.1016/0091-3057(95)00351-7.


The effects of the relatively specific serotonergic agonists 8-OH-DPAT (5-HT1A), TFMPP (5-HT1B), and DOB (5-HT2) were studied on defensive aggressive behavior in rats using the water competition test, 8-OH-DPAT (up to 0.25 mg/kg) and TFMPP (up to 1 mg/kg) were found to be ineffective, whereas DOB (up to 0.4 mg/kg) significantly reduced aggressive behavior in this test as well as in the offensive aggression test of the resident-intruder model. These results, combined with those from other studies, suggest that stimulation of 5-HT1A, 5-HT1B, and 5-HT2 receptors reduces offensive aggression, whereas defensive aggression is only decreased by 5-HT2 stimulation.

MeSH terms

  • Aggression / drug effects*
  • Animals
  • Drinking Behavior / drug effects
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin Receptor Agonists / pharmacology*


  • Serotonin Receptor Agonists