Detection of liver metastases: comparison of superparamagnetic iron oxide-enhanced and unenhanced MR imaging at 1.5 T with dynamic CT, intraoperative US, and percutaneous US

Radiology. 1995 Aug;196(2):471-8. doi: 10.1148/radiology.196.2.7617863.


Purpose: To compare the sensitivities of superparamagnetic iron oxide-enhanced and unenhanced magnetic resonance (MR) imaging at 1.5 T with those of percutaneous ultrasound (US), intraoperative US (IOUS), and dynamic computed tomography (CT) in the preoperative assessment of metastatic liver disease.

Materials and methods: Eighteen patients with liver metastases who were candidates for curative surgery underwent presurgical imaging. Thirteen patients underwent surgery and IOUS after undergoing preoperative US, CT, and MR imaging.

Results: In the preoperative imaging group, the standard of reference was the total number of lesions detected with any of the modalities. Superparamagnetic iron oxide-enhanced MR imaging was the most sensitive modality (99%). In the surgical group, the standard of reference was the total number of metastases identified at IOUS and pathologic examination. IOUS had the highest sensitivity (80%), followed by superparamagnetic iron oxide-enhanced MR imaging (56%).

Conclusion: Superparamagnetic iron oxide-enhanced high-field-strength MR imaging facilitates the preoperative evaluation of potentially curable metastatic liver disease; however, it is inferior to IOUS.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase II
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colorectal Neoplasms / pathology
  • Contrast Media*
  • Dextrans
  • Female
  • Ferrosoferric Oxide
  • Humans
  • Intraoperative Care
  • Iothalamic Acid / analogs & derivatives
  • Iron*
  • Liver / diagnostic imaging
  • Liver / pathology*
  • Liver Neoplasms / diagnosis*
  • Liver Neoplasms / secondary*
  • Liver Neoplasms / surgery
  • Magnetic Resonance Imaging / methods*
  • Magnetite Nanoparticles
  • Male
  • Middle Aged
  • Oxides*
  • Preoperative Care
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed / methods
  • Ultrasonography / methods


  • Contrast Media
  • Dextrans
  • Magnetite Nanoparticles
  • Oxides
  • Iothalamic Acid
  • ioxitalamic acid
  • Iron
  • ferumoxides
  • Ferrosoferric Oxide