Radical differences in CYP1A1 genotype and function

Toxicol Lett. 1995 May;77(1-3):357-62. doi: 10.1016/0378-4274(95)03318-1.

Abstract

The cytochrome P450 1A1 (CYP1A1) gene may be of critical importance in determining individual cancer susceptibility to aromatic hydrocarbons such as those in tobacco smoke. We compared the frequencies of CYP1A1 haplotypes, and complete genotypes, taking into account polymorphisms at 3 sites, including an African-specific polymorphism. No concordance was observed in Africans or African-Americans between any of the 3 polymorphisms, (Msp1 restriction fragment length polymorphism (RFLP)--'M', exon 7--'E', new RFLP--'A') in contrast to the concordance seen between the M and E polymorphisms in Caucasians and Asians. We observed an effect of the E polymorphism on enzyme activity and mRNA induction in Asians and Caucasians.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • African Continental Ancestry Group / genetics
  • Asian Continental Ancestry Group / genetics
  • Base Sequence
  • Continental Population Groups / genetics*
  • Cytochrome P-450 Enzyme System / genetics*
  • European Continental Ancestry Group / genetics
  • Genetics, Population
  • Genotype
  • Humans
  • Molecular Sequence Data
  • Polymorphism, Genetic

Substances

  • Cytochrome P-450 Enzyme System