Radiographic changes and lung function in relation to activity of the glutathione transferases theta and mu among asbestos cement workers

Toxicol Lett. 1995 May;77(1-3):363-9. doi: 10.1016/0378-4274(95)03319-x.


Experimental data indicate that active oxygen species may be casually involved in the development of asbestos-related disease. Thus, it was hypothesized that individual differences in glutathione transferase activity, which may affect the ability to inactivate molecules formed in relation to oxidative stress, could influence the biological response to asbestos exposure. We could, however, not demonstrate an increased risk for radiographic changes or reduced lung function among asbestos cement workers deficient for glutathione transferase theta (GSTT1), glutathione transferase mu (GSTM1), or having a combined deficiency of enzyme activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Asbestos / adverse effects
  • Asbestosis / diagnostic imaging*
  • Asbestosis / enzymology*
  • Asbestosis / physiopathology
  • Glutathione Transferase / analysis*
  • Glutathione Transferase / genetics
  • Humans
  • Isoenzymes / analysis*
  • Lung / physiopathology*
  • Male
  • Middle Aged
  • Occupational Exposure / adverse effects*
  • Polymerase Chain Reaction
  • Polymorphism, Genetic / genetics
  • Radiography
  • Respiratory Function Tests
  • Smoking / adverse effects


  • Isoenzymes
  • Asbestos
  • Glutathione Transferase