Emergence of Functional Circuits in Ferret Visual Cortex Visualized by Optical Imaging

Neuron. 1995 Jul;15(1):23-34. doi: 10.1016/0896-6273(95)90061-6.

Abstract

The emergence of functional lateral interactions in ferret visual cortex was monitored using high speed optical imaging of voltage-sensitive dye signals in brain slices. Prior to the time of eye opening, lateral activation was restricted to a narrow columnar region. During the week following eye opening, the extent of lateral propagation of activity more than doubled. Selective interruption of specific pathways in the slice, combined with pharmacological and anatomical experiments, determined that this lateral propagation was mediated by horizontal projections made within layer 2/3. These results indicate that functional horizontal interactions emerge only after axons begin branching and in parallel with, but not prior to, the refinement of orientation selectivity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Animals
  • Axons / ultrastructure
  • Coloring Agents
  • Evoked Potentials, Visual / drug effects
  • Evoked Potentials, Visual / physiology
  • Ferrets / physiology*
  • Image Processing, Computer-Assisted*
  • Kynurenic Acid / pharmacology
  • Membrane Potentials / physiology
  • Neural Inhibition / physiology
  • Time Factors
  • Visual Cortex / cytology
  • Visual Cortex / physiology*
  • Visual Pathways / cytology
  • Visual Pathways / physiology*

Substances

  • Coloring Agents
  • Kynurenic Acid