T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex

Neuron. 1995 Jul;15(1):63-78. doi: 10.1016/0896-6273(95)90065-9.


The mechanisms that regulate regional specification and evolution of the cerebral cortex are obscure. To this end, we have identified and characterized a novel murine and human gene encoding a putative transcription factor related to the Brachyury (T) gene that is expressed only in postmitotic cells. T-brain-1 (Tbr-1) mRNA is largely restricted to the cerebral cortex, where during embryogenesis it distinguishes domains that we propose may give rise to paleocortex, limbic cortex, and neocortex. Tbr-1 and Id-2 expression in the neocortex have discontinuities that define molecularly distinct neocortical areas. Tbr-1 expression is analyzed in the context of the prosomeric model. Topological maps are proposed for the organization of the dorsal telencephalon.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cerebral Cortex / physiology*
  • Chromosome Mapping
  • Cloning, Molecular
  • DNA / genetics*
  • DNA-Binding Proteins / genetics*
  • Fetal Proteins / genetics*
  • Gene Expression Regulation, Developmental / genetics*
  • Humans
  • In Situ Hybridization
  • Mice
  • Molecular Sequence Data
  • Prosencephalon / physiology
  • Sequence Analysis, DNA
  • Sequence Homology, Nucleic Acid*
  • T-Box Domain Proteins*
  • TATA Box / genetics
  • Thalamus / physiology
  • Transcription Factors / genetics


  • DNA-Binding Proteins
  • Fetal Proteins
  • T-Box Domain Proteins
  • Transcription Factors
  • DNA
  • Brachyury protein

Associated data

  • GENBANK/U49250
  • GENBANK/U49251