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Clinical Trial
. 1995 Mar;39(3):333-6.
doi: 10.1111/j.1365-2125.1995.tb04458.x.

Effects of treatment with simvastatin and pravastatin on cognitive function in patients with hypercholesterolaemia

N Cutler  1 , J Sramek, A Veroff, G Block, L Stauffer, C Lines
Affiliations
Clinical Trial

Effects of treatment with simvastatin and pravastatin on cognitive function in patients with hypercholesterolaemia

N Cutler et al. Br J Clin Pharmacol. 1995 Mar.

Abstract

The effects of equi-efficacious doses of the cholesterol-lowering drugs simvastatin (20 mg day-1) and pravastatin (40 mg day-1) on tests of cognitive function were investigated in a double-blind, placebo-controlled, 2-period (4 weeks per period), incomplete block, crossover study of 36 patients (24 per treatment) with hypercholesterolaemia. After 4 weeks neither of the active treatments differed significantly from placebo on any cognitive measure.

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