A Xenopus c-kit-related receptor tyrosine kinase expressed in migrating stem cells of the lateral line system

Mech Dev. 1995 Apr;50(2-3):217-28. doi: 10.1016/0925-4773(94)00338-n.

Abstract

The mammalian c-kit receptor tyrosine kinase gene is required during embryogenesis for the survival and/or proliferation of three migrating stem cell populations: primordial germ cells, haematopoietic stem cells and neural crest-derived melanoblasts. We have cloned a Xenopus gene, XKrk1, whose closest relative is c-kit. Differences in the expression pattern suggest that XKrk1 is not the Xenopus homologue of c-kit; however, it is expressed in a migrating stem cell population, the precursor cells for the mechanosensory lateral line system. XKrk1 is the first reported marker for lateral line stem cells.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Movement
  • Gene Expression Regulation, Developmental / physiology*
  • Mechanoreceptors / embryology*
  • Molecular Sequence Data
  • Receptor Protein-Tyrosine Kinases / genetics*
  • Sequence Homology, Amino Acid
  • Stem Cells / cytology*
  • Xenopus

Substances

  • Receptor Protein-Tyrosine Kinases

Associated data

  • GENBANK/Z48770