Gastroesophageal reflux laryngitis resistant to omeprazole therapy

J Voice. 1995 Jun;9(2):205-11. doi: 10.1016/s0892-1997(05)80254-1.


Gastroesophageal reflux disease (GERD) is known to cause a variety of symptoms that lead a patient to seek otolaryngologic care. New advances in the treatment of GERD have enabled otolaryngologists to eliminate most of the signs and symptoms caused by acid reflux. Omeprazole, the most recent pharmacologic advancement, has been reported to be universally successful in controlling acid release from the stomach of patients with GERD. This report describes a series of patients with GERD for whom high-dose omeprazole therapy was not successful in completely reducing gastric acid levels of GERD symptomatology.

MeSH terms

  • Adult
  • Aged
  • Female
  • Gastroesophageal Reflux / complications*
  • Gastroesophageal Reflux / drug therapy*
  • Humans
  • Laryngitis / complications*
  • Laryngitis / drug therapy*
  • Male
  • Middle Aged
  • Omeprazole / administration & dosage
  • Omeprazole / adverse effects
  • Omeprazole / therapeutic use*
  • Retrospective Studies


  • Omeprazole