Inhibitory effect of FUT-175 on the production of interleukin 8 and polymorphonuclear leukocyte elastase

Res Commun Mol Pathol Pharmacol. 1995 Mar;87(3):269-74.

Abstract

We investigated the inhibitory effects of a protease inhibitor, FUT-175, on the production of interleukin 8 (IL-8) and polymorphonuclear leukocyte elastase (PMNE) by polymorphonuclear leukocytes (PMN) and vascular endothelial cells. IL-8 production by PMN and vascular endothelial cells stimulated with lipopolysaccharide (LPS) was inhibited by FUT-175. This compound also inhibited PMNE production by PMN following LPS stimulation.

MeSH terms

  • Benzamidines
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / enzymology
  • Endothelium, Vascular / metabolism
  • Guanidines / pharmacology*
  • Humans
  • Interleukin-8 / antagonists & inhibitors*
  • Interleukin-8 / biosynthesis
  • Interleukin-8 / blood
  • Leukocyte Elastase
  • Lipopolysaccharides / pharmacology
  • Neutrophils / drug effects*
  • Neutrophils / enzymology
  • Neutrophils / metabolism
  • Pancreatic Elastase / antagonists & inhibitors*
  • Pancreatic Elastase / biosynthesis
  • Pancreatic Elastase / blood
  • Protease Inhibitors / pharmacology*
  • Stimulation, Chemical

Substances

  • Benzamidines
  • Guanidines
  • Interleukin-8
  • Lipopolysaccharides
  • Protease Inhibitors
  • Pancreatic Elastase
  • Leukocyte Elastase
  • nafamostat