Nifedipine-induced gingival hyperplasia. A comprehensive review and analysis

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Jun;79(6):715-22. doi: 10.1016/s1079-2104(05)80306-3.


A comprehensive review of the literature and analysis of the clinical history, mechanisms, pathogenesis, histology, and management of nifedipine-induced gingival hyperplasia is reported. A correlation to age, gender, drug, dosage, duration of drug therapy, location, and mode of treatment is discussed. The case report presented provides a model for management of nifedipine-induced gingival hyperplasia and other drug-induced gingival hyperplasia.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Calcium / metabolism
  • Female
  • Gingival Hyperplasia / chemically induced*
  • Gingival Hyperplasia / surgery
  • Gingivoplasty
  • Humans
  • Middle Aged
  • Nifedipine / adverse effects*


  • Nifedipine
  • Calcium