Familial prolactinoma

Clin Endocrinol (Oxf). 1995 May;42(5):483-6. doi: 10.1111/j.1365-2265.1995.tb02666.x.


Background: Apart from the rare association with type I multiple endocrine neoplasia (MEN-1), familial types of prolactinoma have not been reported.

Patients and measurements: Eight hyperprolactinaemic patients in four families and 18 of their first and second-degree relatives (parents, children and grandchildren) were examined. Hormone levels were measured, as well as other biochemical parameters.

Results: Prolactinoma was diagnosed in more than one member of each of the four families.

Conclusion: Familial prolactinoma is a distinct entity which is probably due to a genetic mutation promoting lactotroph proliferation.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Humans
  • Hyperprolactinemia / blood
  • Hyperprolactinemia / genetics*
  • Male
  • Middle Aged
  • Pedigree
  • Pituitary Neoplasms / blood
  • Pituitary Neoplasms / genetics*
  • Prolactinoma / blood
  • Prolactinoma / genetics*