Cloning of the gene encoding human somatostatin receptor 2: sequence analysis of the 5'-flanking promoter region

M T Greenwood; L A Robertson; Y C Patel

doi:10.1016/0378-1119(95)00059-f

Cloning of the gene encoding human somatostatin receptor 2: sequence analysis of the 5'-flanking promoter region

Gene. 1995 Jul 4;159(2):291-2. doi: 10.1016/0378-1119(95)00059-f.

Authors

M T Greenwood¹, L A Robertson, Y C Patel

Affiliation

¹ Fraser Laboratories, Department of Medicine, McGill University, Royal Victoria Hospital, Montreal, Québec, Canada.

PMID: 7622071
DOI: 10.1016/0378-1119(95)00059-f

Abstract

Using a cDNA probe, genomic clones were obtained for the 5' flanking promoter sequence of the human somatostatin receptor 2-encoding gene (SSTR2). A 3.8-kb sequence directly upstream from the start codon was analyzed. This sequence shares a number of characteristics with the promoters of other G-protein-coupled receptor (GPCR)-encoding genes including a number of G+C-rich regions, binding sites for several transcriptional factors, and the absence of coupled TATAA and CAAT sequences.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Cloning, Molecular
Humans
Molecular Sequence Data
Promoter Regions, Genetic / genetics*
Receptors, Somatostatin / genetics*
Sequence Analysis, DNA

Substances

Receptors, Somatostatin
somatostatin receptor 2

Associated data

GENBANK/L34689